When to Use Naloxone

When to Use Naloxone

Opioid overdoses can happen unexpectedly, and knowing what to look for can help you decide when to act. If you're not familiar with naloxone itself, our What is Naloxone page covers the basics. This guide focuses on recognizing an overdose and knowing when naloxone applies.

Recognizing an Opioid Overdose

Common signs of an opioid overdose include slowed, irregular, or stopped breathing, unresponsiveness, bluish or gray lips and fingernails, and pinpoint pupils. If you notice these signs in someone, it's worth calling 911 and considering naloxone.

Situations Where Naloxone May Apply

A few situations where naloxone commonly comes into play:

Someone is found unresponsive after suspected opioid use, or shows slowed or stopped breathing following use of a painkiller, heroin, or fentanyl. Someone mixes opioids with alcohol or sedatives and becomes unresponsive. A child or pet accidentally gets into prescription opioids. Or you're simply not sure what someone has taken, but the signs match an overdose.

Since naloxone has no effect on someone who hasn't taken opioids, there's little downside to using it if you're unsure.

What to Do Next

For a complete, detailed breakdown of overdose signs, along with step-by-step guidance on giving naloxone and what to do afterward, we point to SAMHSA rather than write our own version. Review SAMHSA's Overdose Prevention and Response Toolkit for the full picture, or see our How to Use Naloxone page for administration and what to expect afterward.

Visit our Naloxone Provider Directory if you don't already have naloxone on hand.

Disclaimer

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